Mass spectrometry is a powerful analytical tool used for the analysis of
a wide range of substances and matrices; it is increasingly utilized for
clinical applications in laboratory medicine. This Primer includes an
overview of basic mass spectrometry concepts, focusing primarily on
tandem mass spectrometry. We discuss experimental considerations
and quality management, and provide an overview of some key
applications in the clinic. Lastly, the Primer discusses significant
challenges for implementation of mass spectrometry in clinical
laboratories and provides an outlook of where there are emerging
clinical applications for this technology.
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